Evaluation of the Cepheid® Xpert®C. difficile binary toxin (BT) diagnostic assay. (June 2018)

• Record Type: Journal Article
• Authors: McGovern, Alan M.; Androga, Grace O.; Moono, Peter; Collins, Deirdre A.; Foster, Niki F.; Chang, Barbara J.; Riley, Thomas V.
• Is Part Of: Anaerobe. Volume 51(2018)
• Page Start: 12
• Page End: 16
• Publication Date: 2018-06
• Subjects: Clostridium difficile infection -- Binary toxin -- CDT -- Piglets -- Diagnostics; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2018.03.004
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Strains of Clostridium difficile producing only binary toxin (CDT) are found commonly in animals but not humans. However, human diagnostic tests rarely look for CDT. The Cepheid Xpert C. difficile BT assay detects CDT with equal sensitivity (≥92%) in human and animal faecal samples. Highlights: Clostridium difficile binary toxin (CDT) is not detected by most diagnostic tests. The Cepheid Xpert C. difficile BT assay reports CDT regardless of other toxins. The assay is equally sensitive (≥92%) in both human and animal samples.