Natriuretic peptides and their receptors in failing heart – Functional changes and implications for treatment. (15th August 2018)

• Record Type: Journal Article
• Authors: Kodziszewska, Katarzyna; Sochanowicz, Barbara; Brzóska, Kamil; Kuśmierczyk, Mariusz; Kuśmierski, Krzysztof; Śmigielski, Witold; Piotrowski, Walerian; Kruszewski, Marcin; Leszek, Przemyslaw
• Is Part Of: International journal of cardiology. Volume 265(2018)
• Page Start: 135
• Page End: 140
• Publication Date: 2018-08-15
• Subjects: Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2018.04.027
• Languages: English
• ISSNs: 0167-5273

Abstract

Highlights: Heart failure leads to altered cardiac expression of natriuretic peptides on transcriptional and transcriptional level. Expression of NPR-A and NPR-B remains unaltered in failing hearts. Function of NPR-A receptor becomes attenuated in failing hearts, while NPR-B function remains unaltered. Cardiac expression of NPR-C changes on both transcriptional and translational level patients with heart failure. Expression of NPR-C in failing hearts varies depending on the etiology of HF.