Highly reactive crystalline-phase-embedded strontium-bioactive nanorods for multimodal bioactive applications. (29th May 2018)

• Record Type: Journal Article
• Authors: Durgalakshmi, D.; Ajay Rakkesh, R.; Kesavan, M.; Ganapathy, S.; Ajithkumar, T. G.; Karthikeyan, S.; Balakumar, S.
• Is Part Of: Biomaterials science. Volume 6:Number 7(2018)
• Page Start: 1764
• Page End: 1776
• Publication Date: 2018-05-29
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c8bm00362a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : In the present work, strontium incorporated bioactive material was synthesised using sol–gel assisted microwave method for multimodal bioactive applications in the field of bone and dentistry. Abstract : In the present work, a crystallization-induced strontium-bioactive material, with a composition similar to Bioglass 45S5 system, was obtained using a sol–gel-assisted microwave method with nanorod morphologies of 30–80 nm in size. The effect of crystallization induced in the glass network, and its influence on the bioactivity and mechanical properties of bone and dentin regeneration, were the main novel findings of this work. Rietveld analysis of X-ray diffraction spectra showed the best fit with sodium (combeite, Na2 Ca2 Si3 O9 ) and calcium (clinophosinaite, Ca2 Na6 O14 P2 Si2 ; calcium strontium silicate, Ca1.5 O4 SiSr0.5 ; and calcium carbonate, CaCO3 ) enriched crystal systems. Multinuclear solid-state NMR studies provided detailed atomistic insight into the presence of crystalline mineral phases in the bioactive material. The dentin matrix and antibacterial studies showed good results for 5% strontium-substituted calcium compared with basic 45S5 composition due to its smaller particle size (30 nm), which suggested applications to dentin regeneration. Simulation studies have been demonstrated with clinophosinaite crystal data from the XRD spectra, with the glycoprotein salivary metabolites also showing that 5% strontium-substituted calcium has a higher binding affinity for the salivary compound, which is suitable for dentin regeneration applications. In vitro apatite formation studies showed that this material is suitable for bone regeneration applications.