Hepatitis A vaccine immune response 22 years after vaccination. Issue 8 (1st May 2018)

• Record Type: Journal Article
• Authors: Mosites, Emily; Gounder, Prabhu; Snowball, Mary; Morris, Julie; Spradling, Philip; Nelson, Noele; Bulkow, Lisa; Bruce, Michael; McMahon, Brian
• Is Part Of: Journal of medical virology. Volume 90:Issue 8(2018)
• Page Start: 1418
• Page End: 1422
• Publication Date: 2018-05-01
• Subjects: Hepatitis A virus -- Immunization -- Vaccines; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25197
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : In the United States, the incidence of hepatitis A virus (HAV) infection has been reduced through universal childhood vaccination. However, the duration of immunogenicity for the hepatitis A vaccine is not known. We report on the 22 year follow‐up time point of a cohort of Alaska children who were randomized to three different vaccine schedules: A) 0, 1, and 2 months; B) 0, 1, and 6 months; and C) 0, 1, and 12 months. Among 46 participant available for follow‐up, 40 (87%) maintained protective levels of anti‐hepatitis A antibody. These results indicate that a supplemental booster dose is not yet necessary at or before the 22‐year time point.