Targeted Delivery of DNA‐Au Nanoparticles across the Blood–Brain Barrier Using Focused Ultrasound. (6th June 2018)

• Record Type: Journal Article
• Authors: Chan, Tiffany G.; Morse, Sophie V.; Copping, Matthew J.; Choi, James J.; Vilar, Ramon
• Is Part Of: ChemMedChem. Volume 13:Number 13(2018)
• Page Start: 1311
• Page End: 1314
• Publication Date: 2018-06-06
• Subjects: blood–brain barrier -- brain -- DNA -- nanoparticles -- ultrasound; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201800262
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood–brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA‐coated gold nanoparticles to specific locations in the brains of mice. Abstract : Getting cerebral : Treatment and imaging of the brain is often limited by the inability of drugs and probes to cross the blood–brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA‐coated and optically labelled gold nanoparticles to specific locations in the brains of mice.