Influence of Functionalized η6‐Arene Rings on Ruthenium(II) Curcuminoids Complexes. Issue 23 (20th June 2018)

• Record Type: Journal Article
• Authors: Pettinari, Riccardo; Petrini, Agnese; Marchetti, Fabio; Di Nicola, Corrado; Scopelliti, Rosario; Riedel, Tina; Pittet, Laure D.; Galindo, Agustín; Dyson., Paul J.
• Is Part Of: ChemistrySelect. Volume 3:Issue 23(2018)
• Page Start: 6696
• Page End: 6700
• Publication Date: 2018-06-20
• Subjects: Anticancer activity -- Bisdemethoxycurcumin -- Curcumin -- Ruthenium-arene complexes; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201801201
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A series of organometallic Ru(II) complexes containing functionalized η 6 ‐arene ligands, together with curcumin and bisdemethoxycurcumin as O, O'‐chelating ligands and their RAPTA (ruthenium arene complexes bearing the 1, 3, 5‐triaza‐7‐phosphaadamantane ligand) type ionic derivatives is reported. The complexes were characterized by elemental analysis, infrared, 1 H and 13 C NMR, ESI‐MS spectrometry, and by single‐crystal X‐ray structure analysis. The cytotoxic activity of the complexes has been evaluated against human ovarian A2780 and A2780cisR cancer cell lines as well as non‐tumorigenic human embryonic kidney HEK 293 cells. Abstract : In this article, we reported a series of heteroleptic Ru(II) complexes containing functionalized η 6 ‐arene ligands, together with curcumin and bisdemethoxycurcumin and their ionic derivatives with 1, 3, 5‐triaza‐7‐phosphaadamantane (PTA). The complexes were characterized by elemental analysis, infrared, NMR, ESI‐MS spectrometry, and by single‐crystal X‐ray structure analysis. Curcumins and functionalized η 6 ‐arene, are considerably less cytotoxic than non‐functionalized analogues toward human ovarian A2780 and A2780cisR cancer cell lines.