Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins12. Issue 26 (12th June 2018)

• Record Type: Journal Article
• Authors: Sarkar, Rahul; Mitra, Sankash; Mukherjee, Santanu
• Is Part Of: Chemical science. Volume 9:Issue 26(2018)
• Page Start: 5767
• Page End: 5772
• Publication Date: 2018-06-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8sc02041h
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er). Abstract : The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er).