Alterations of Gray Matter Volume and White Matter Integrity in Maternal Deprivation Monkeys. (1st August 2018)

• Record Type: Journal Article
• Authors: Wang, Jiaojian; Feng, Xiaoli; Wu, Jing; Xie, Sangma; Li, Ling; Xu, Liqi; Zhang, Yuhua; Ren, Xiaofeng; Hu, Zhengfei; Lv, Longbao; Hu, Xintian; Jiang, Tianzi
• Is Part Of: Neuroscience. Volume 384(2018)
• Page Start: 14
• Page End: 20
• Publication Date: 2018-08-01
• Subjects: DTI diffusion tensor imaging -- FA flip angle -- FA fractional anisotropy -- FOV field of view -- GMV gray matter volume -- MD Maternal deprivation -- MRI magnetic resonance imaging -- NC normal control -- PET positron emission tomography -- pSTS posterior superior temporal sulcus -- ROI region of interest -- SD standard deviation -- STS superior temporal sulcus -- TBSS tract-based spatial statistics -- TE echo time -- TFCE threshold-free cluster enhancement -- TR repetition time -- VBA voxel-based analysis -- VBM voxel-based morphology -- WMI white matter integrity; maternal deprivation -- rhesus monkey -- gray matter volume -- white matter integrity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2018.05.020
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Maternal deprivation monkeys used to model early stress. Reduced gray matter volume found in V1. Increased FA identified in posterior superior temporal sulcus. FA in posterior superior temporal sulcus can predict behavioral performances. Abstract: Maternal deprivation (MD) in rhesus monkeys has been demonstrated to be an effective model to mimic early adversity in humans because of the close phylogenetic similarity affinity. Although behavioral and hormonal abnormalities have been observed in MD monkeys, the neurobiological underpinning of the long-term deleterious effect of MD on monkeys is still unclear. In this study, we assessed emotional changes and socio-behavioral abnormalities induced by long-term MD and assessed structural alterations of gray matter volume (GMV) and white matter integrity (WMI) in 15 MD rhesus monkeys and in 15 age-, gender-matched normal controls (NC) using voxel-based morphology and voxel-based analysis methods. We found increased stereotypical behavioral durations and decreased social grooming durations in MD monkeys. Reduced GMV in the primary visual cortex (V1) and increased fractional anisotropy (FA) in the left posterior superior temporal sulcus (pSTS) was also found in MD monkeys. Moreover, the mean FA values in pSTS showed positive correlation with the stereotypical behavioral durations in MD monkeys and negative correlation with social grooming durations in NC monkeys. Our findings indicated that the deleterious effects of MD on rhesus monkeys resulted in structural abnormalities in the visual cortex and premature myelination in the pSTS. These findings provide new insights into understanding the impact of maternal deprivation on the neurological basis of brain development.