Chikungunya Virus Infection Associated with Encephalitis and Anterior Uveitis. (4th July 2018)

• Record Type: Journal Article
• Authors: Rocha, Verônica França Diniz; de Oliveira, Adriano Hasler Principe; Bandeira, Antonio Carlos; Sardi, Silvia Ines; Garcia, Rodrigo Freaza; Magalhães, Samuel de Araújo; Sampaio, Camila Alves; Campos Soares, Gubio
• Is Part Of: Ocular immunology and inflammation. Volume 26:Number 5(2018)
• Page Start: 677
• Page End: 679
• Publication Date: 2018-07-04
• Subjects: Anterior uveitis -- Chikungunya uveitis -- CHIKV encephalitis -- CHIKV uveitis -- cotton wool spots; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2017.1358378
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Chikungunya virus (CHIKV) is an RNA virus transmitted by Aedes mosquitoes. The clinical manifestations include fever, arthralgia, rash, and other atypical clinical findings including ocular lesions. We report the case of a 57-year-old man with meningoencephalitis and anterior uveitis due to CHIKV. The patient had developed bilateral anterior uveitis with iris atrophy and a cotton wool spot on the left eye, and his serum, urine, saliva, and cerebrospinal fluid were positive for CHIKV by RT-PCR. The spectrum of the ophthalmologic manifestations and its pathophysiology in cases of CHIKV infections needs to be better understood. Additional studies examining the ocular lesions caused by CHIKV could improve the therapeutic goals of reducing the morbidity and sequels.