In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly. Issue 21 (24th April 2018)

• Record Type: Journal Article
• Authors: Ferji, Khalid; Venturini, Pierre; Cleymand, Franck; Chassenieux, Christophe; Six, Jean-Luc
• Is Part Of: Polymer chemistry. Volume 9:Issue 21(2018)
• Page Start: 2868
• Page End: 2872
• Publication Date: 2018-04-24
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c8py00346g
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : A broad set of advanced glyco-nanostructures, rarely obtained as vesicles or never reported as wormlike micelles, is obtained using photo-initiated Polymerization-Induced Self-Assembly (Photo-PISA). Abstract : Frequently, the classical self-assembly techniques applied to amphiphilic glycopolymers lead to primitive morphologies, i.e. spherical micelles/nanoparticles. Herein, we report a facile and rapid one-pot synthesis and self-assembly of grafted amphiphilic glycopolymers using photo-initiated Polymerization-Induced Self-Assembly (Photo-PISA) under UV-irradiation at room temperature. Such glycopolymers were based on dextran as a hydrophilic steric stabilizer backbone and poly(hydroxypropyl methacrylate) PHPMA as a hydrophobic graft. Transmission electron microscopy and light scattering analysis reveal the formation of a broad set of advanced glyco-nanostructures ranging from spherical micelles to worm-like micelles and vesicles depending on both the PHPMA graft length and the solids content.