Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens. Issue 42 (2nd July 2018)

• Record Type: Journal Article
• Authors: Zhang, Shuaibing; Huang, Ying; He, Shijun; Chen, Heping; Li, Zhenghui; Wu, Bin; Zuo, Jianping; Feng, Tao; Liu, Jikai
• Is Part Of: RSC advances. Volume 8:Issue 42(2018)
• Page Start: 23914
• Page End: 23918
• Publication Date: 2018-07-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra04226h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A chemical study of the common species Albatrellus confluens present in Yunnan province, southwest China led to the identification of a pair of epimers named albatredines A (1 ) and B (2 ). Abstract : A chemical study of the common species Albatrellus confluens present in Yunnan province, southwest China led to the identification of a pair of epimers named albatredines A (1 ) and B (2 ). They feature a natural unprecedented 1, 2, 4-oxadiazolidin-5-one skeleton. The acyl substitution pattern and complete configurational assignments were deduced from the comparison between experimental and theoretical 13 C NMR and ECD data, respectively. Bioassay results showed that compound1 exhibited a weak immunosuppressive activity against the concanavalin A-induced T lymphocyte cell proliferation (IC50 2.99 μM).