Chemoselective synthesis of aryl(pyridinyl)methanol derivatives through Ni-NIXANTPHOS catalyzed α-arylation and tandem arylation/rearrangement of pyridylmethyl ethers. Issue 12 (3rd April 2018)

• Record Type: Journal Article
• Authors: Liu, Zhengfen; Li, Minyan; Wang, Bijun; Deng, Guogang; Chen, Wen; Kim, Byeong-Seon; Zhang, Hongbin; Yang, Xiaodong; Walsh, Patrick J.
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 12(2018)
• Page Start: 1870
• Page End: 1876
• Publication Date: 2018-04-03
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo00207j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient synthesis of aryl(pyridyl)-methanol derivatives using Ni-NIXANTPHOS catalyzed α-arylation and tandem arylation/rearrangement is described. Abstract : An efficient synthesis of aryl(pyridyl)-methanol derivatives using a nickel-NIXANTPHOS catalyst is described. Combinations of the Ni-NIXANTPHOS catalyst, solvent, and reaction temperature achieved chemoselective arylation and tandem arylation/rearrangement of pyridylmethyl ethers. A large variety of aryl halides were tolerated (55 examples, up to 96% yield). The scalability of the reaction is demonstrated. The order of the tandem arylation and [1, 2]-Wittig rearrangement was probed by comparative studies.