Highly antiproliferative neutral Ru(ii)-arene phosphine complexes. (30th January 2018)

• Record Type: Journal Article
• Authors: Chotard, Florian; Dondaine, Lucile; Balan, Cédric; Bettaïeb, Ali; Paul, Catherine; Le Gendre, Pierre; Bodio, Ewen
• Is Part Of: New journal of chemistry. Volume 42:Number 10(2018)
• Page Start: 8105
• Page End: 8112
• Publication Date: 2018-01-30
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj04442a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The introduction of a benzoate ligand dramatically increases the ruthenium uptake in cells, leading to a low micromolar IC50 . Abstract : Six ruthenium(ii )- and four gold(i )-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(ii ) complexes displayed an IC50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.