Bioactivity-guided isolation of chemical constituents against H2O2-induced neurotoxicity on PC12 from Cimicifuga dahurica (Turcz.) Maxim. Issue 15 (1st August 2017)

• Record Type: Journal Article
• Authors: Lv, Chongning; Yang, Fan; Qin, Rulan; Qi, Zheyuan; Zhou, Wanrong; Lu, Jincai
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 15(2017)
• Page Start: 3305
• Page End: 3309
• Publication Date: 2017-08-01
• Subjects: Cimicifuga dahurica (Turcz.) Maxim. -- Cyclolanostane triterpenes -- Piscidic acid derivatives -- Neuro-protective; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.06.020
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Three new compounds (1, 6, 9 ), with six known compounds (2 –5, 7 –8 ) were obtained from water-soluble extract of Cimicifuga dahurica (Turcz.) Maxim. by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. H2 O2 -induced neurotoxicity on PC12 cells model were conducted to evaluate the neuro-protective capability of these compounds. The piscidic acid derivatives compounds4 –7 showed marked neuro-protective effect at certain concentration.