Bleeding complications after myocardial infarction in a real world population - An observational retrospective study with a sex perspective. Issue 167 (July 2018)

• Record Type: Journal Article
• Authors: Holm, Anna; Lawesson, Sofia Sederholm; Zolfagharian, Shima; Swahn, Eva; Ekstedt, Mattias; Alfredsson, Joakim
• Is Part Of: Thrombosis research. Issue 167(2018)
• Page Start: 156
• Page End: 163
• Publication Date: 2018-07
• Subjects: Myocardial infarction -- Bleeding -- Sex -- Mortality; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2018.05.023
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Introduction: The aim of the current study was to assess bleeding events, including severity, localisation and prognostic impact, in a real world population of men and women with myocardial infarction (MI). Methods and results: In total 850 consecutive patients were included during 2010 and followed for one year. Bleeding complications were identified by searching of each patients' medical records and characterised according to the TIMI criteria. For this analysis, only the first event was calculated. The total incidence of bleeding events was 24.4% (81 women and 126 men, p = ns). The incidence of all in-hospital bleeding events was 13.2%, with no sex difference. Women had significantly more minor non-surgery related bleeding events than men (5% vs 2.2%, p = 0.02). During follow-up, 13.5% had a bleeding, with more non-surgery related bleeding events among women, 14.7% vs 9.7% (p = 0.03). The most common bleeding localisation was the gastrointestinal tract, more in women than men (12.1% vs 7.6%, p = 0.03). Women had also more access site bleeding complications (4% vs 1.7%, p = 0.04), while men had more surgery related bleeding complications (6.4% vs 0.9%, p ≤0.001). Increased mortality was found only in men with non-surgery related bleeding events (p = 0.008). Conclusions: Almost one in four patients experienced a bleeding complication through 12 months follow-up after a myocardial infarction. Women experienced more non-surgery related minor/minimal bleeding complications than men, predominantly GI bleeding events and access site bleeding events, with no apparent impact on outcome. In contrast men with non-surgery related bleeding complications had higher mortality. Improved bleeding prevention strategies are warranted for both men and women. Highlights: Frequent bleeding in patients with myocardial infarction after the acute event Women bled more but with low impact on mortality. Women had more gastro-intestinal bleeding events than men. Men with bleeding events had increased mortality than non-bleeding men.