Cyclodextrins as excipients in tablet formulations. Issue 6 (June 2018)

• Record Type: Journal Article
• Authors: Conceição, Jaime; Adeoye, Oluwatomide; Cabral-Marques, Helena Maria; Lobo, José Manuel Sousa
• Is Part Of: Drug discovery today. Volume 23:Issue 6(2018)
• Page Start: 1274
• Page End: 1284
• Publication Date: 2018-06
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2018.04.009
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: Cyclodextrins are complexing excipients in tablets mainly for potent drugs. Methods to enhance the complexation efficiency decrease the cyclodextrin quantity. Inclusion complex flow properties play a crucial part in the tablet manufacture process. Commercial tablets containing cyclodextrins are available on the market. 3D-printed tablets can be developed containing cyclodextrins as excipients. Abstract : This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets.