Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior. (July 2015)

• Record Type: Journal Article
• Authors: Pardun, Karoline; Treccani, Laura; Volkmann, Eike; Streckbein, Philipp; Heiss, Christian; Gerlach, Juergen W; Maendl, Stephan; Rezwan, Kurosch
• Is Part Of: Journal of biomaterials applications. Volume 30:Number 1(2015:Jul.)
• Page Start: 104
• Page End: 118
• Publication Date: 2015-07
• Subjects: Zirconia -- calcium phosphate -- magnesium -- bioactivity -- implant coating; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328215572428
• Languages: English
• ISSNs: 0885-3282

Abstract

An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg 2+ ions. The magnesium-containing coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.