Use of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and PROK1/PAPP-A ratio to predict adverse pregnancy outcomes in the first trimester: a prospective study. (18th October 2018)

• Record Type: Journal Article
• Authors: Inan, Cihan; Varol, Fusun Gulizar; Erzincan, Selen Gursoy; Uzun, Isil; Sutcu, Havva; Sayin, N. Cenk
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 31:Number 20(2018)
• Page Start: 2685
• Page End: 2692
• Publication Date: 2018-10-18
• Subjects: Foetal growth retardation; gestational diabetes mellitus -- preeclampsia -- preterm birth -- prokinecin 1; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2017.1351536
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Introduction: To compare the predictive effectiveness levels of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and the PROK1/PAPP-A ratio in the first trimester for preeclampsia (PE), foetal growth restriction (FGR), gestational diabetes mellitus (GDM) and spontaneous preterm birth (SPB). Materials and methods: A total of randomly selected 162 pregnant women were included. Peripheral blood samples were obtained between 11 0/7 and 13 6/7 gestational weeks (GWs). All women were followed throughout the pregnancy and classified into five groups as having PE, FGR, GDM, SPB and uncomplicated pregnancies. The cut-off levels of the markers were identified to predict adverse outcomes. Results: PROK1 predicted PE with 83.3% sensitivity, 85.7% specificity at a value of >293.4 pg/mL; at a value of >260.2 pg/mL, PROK1 predicted FGR with 85.7% sensitivity, 72.5% specificity in the first trimester. The area under receiver operating characteristic (ROC) curve of PAPP-A was lower than that of PROK1 and PROK1/PAPP-A in differentiating PE and FGR from the uncomplicated group ( p < .001). PROK1 levels and the PROK1/PAPP-A ratios in the SPB and GDM groups were lower than in the uncomplicated group ( p < .01). Conclusions: Elevated PROK1 in the first trimester is a more effective marker than PAPP-A in the prediction of PE and FGR. Lower PROK1 levels are associated with the development of SPB and GDM.