Convenient one-pot synthesis and biological evaluation of phosphoramidates and phosphonates containing heterocycles. (3rd July 2018)

• Record Type: Journal Article
• Authors: Nayab Rasool, SK.; Subramanyam, Ch.; Janakiramudu, D. B.; Supraja, P.; Usha, R.; Raju, C. Naga
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 193:Number 7(2018)
• Page Start: 470
• Page End: 474
• Publication Date: 2018-07-03
• Subjects: Phosphoramidates -- Antimicrobial activity -- Diethyl phosphorochloridate -- Alkyl/aryl amines; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2018.1452229
• Languages: English
• ISSNs: 1042-6507

Abstract

GRAPHICAL ABSTRACT: ABSTRACT: A series of new phosphoramidates and phosphonates were synthesized in single step by reacting diethyl phosphorochloridate with various bioactive amines. The newly synthesized compounds3a-j were tested for antibacterial activity against Gram-positive and Gram-negative bacteria. All the title compounds exhibited good activity. Amongst all the tested compounds, 3b (diethyl(4-(6-fluorobenzo(d)isoxazol-3-yl)piperidin-1-yl)phosphonate), 3c (diethyl 4, 6-difluorobenzo(d)thiazole-2-ylphosphoramidate) and3d (diethyl 5-nitro-1 H -indazol-1-yl- phosphonate) displayed promising antimicrobial activity against Pseudomonas aeruginosa and Trichoderma viride due to the presence of electron with drawing fluoro and nitro groups respectively.