Non-coding RNAs in virology: an RNA genomics approach. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Isaac, Christopher; Patel, Trushar R.; Zovoilis, Athanasios
• Is Part Of: Biotechnology and genetic engineering reviews. Volume 34:Issue 1(2018)
• Page Start: 90
• Page End: 106
• Publication Date: 2018-01-02
• Subjects: Non-coding RNAs -- miRNAs -- lncRNAs -- SINE RNAs -- viral infection -- next-generation sequencing -- RNA bioinformatics; ncRNAs: non-coding RNAs; Biotechnology -- Periodicals; Genetic engineering -- Periodicals; Biochemical engineering -- Periodicals; Biomedical Engineering -- Periodicals; Environmental Microbiology -- Periodicals; Genetic Engineering -- Periodicals; Microbiological Techniques -- Periodicals; Technology -- Periodicals; Periodicals; 660.605
• DOI: 10.1080/02648725.2018.1471642
• Languages: English
• ISSNs: 0264-8725

Abstract

Abstract: Advances in sequencing technologies and bioinformatic analysis techniques have greatly improved our understanding of various classes of RNAs and their functions. Despite not coding for proteins, non-coding RNAs (ncRNAs) are emerging as essential biomolecules fundamental for cellular functions and cell survival. Interestingly, ncRNAs produced by viruses not only control the expression of viral genes, but also influence host cell regulation and circumvent host innate immune response. Correspondingly, ncRNAs produced by the host genome can play a key role in host–virus interactions. In this article, we will first discuss a number of types of viral and mammalian ncRNAs associated with viral infections. Subsequently, we also describe the new possibilities and opportunities that RNA genomics and next-generation sequencing technologies provide for studying ncRNAs in virology.