Versatility of the Biginelli reaction: Synthesis of new biphenyl dihydropyrimidin-2-thiones using different ketones as building blocks. Issue 28 (11th July 2018)

• Record Type: Journal Article
• Authors: Gonçalves, Itamar Luís; Davi, Leonardo; Rockenbach, Liliana; das Neves, Gustavo Machado; Kagami, Luciano Porto; Canto, Rômulo Faria Santos; Figueiró, Fabrício; Battastini, Ana Maria Oliveira; Eifler-Lima, Vera Lucia
• Is Part Of: Tetrahedron letters. Volume 59:Issue 28(2018)
• Page Start: 2759
• Page End: 2762
• Publication Date: 2018-07-11
• Subjects: Biginelli reaction -- Structural diversity -- Multicomponent reaction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.06.006
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Biphenyl dihydropyrimidin-2-thiones were synthesized via Biginelli reaction. The synthesis was performed using simple ketones and di-ketones as starting materials. Products could be obtained in high yield and purity after easy work-up (filtration and recrystallization). Abstract: A multi-component synthesis of biphenyl dihydropyrimidin-2-thiones from 1-phenylthiourea, aldehydes and ketones or di-ketones has been demonstrated. The reaction proceeded well for aldehydes with electron donor or acceptor substituents under mild conditions.