Mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of mice with MPTP-induced Parkinson's disease. (July 2018)

• Record Type: Journal Article
• Authors: Kusuda, Yuina; Takemura, Ai; Nakano, Masaki; Ishihara, Akihiko
• Is Part Of: Neuroscience research. Volume 132(2018)
• Page Start: 58
• Page End: 62
• Publication Date: 2018-07
• Subjects: Balance beam test -- Dissolved oxygen -- Enhanced atmosphere absolute -- Immunohistochemistry -- Increased oxygen concentration -- Oxidative metabolism -- Rotarod test; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2017.11.008
• Languages: English
• ISSNs: 0168-0102

Abstract

Highlights: We examined effects of mild hyperbaric oxygen on dopaminergic neurons in the substantia nigra of an animal model with Parkinson's disease. Mice injected with MPTP and probenecid were exposed to 1317 hPa with 45% oxygen. The decrease in dopaminergic neurons in mice with Parkinson's disease was inhibited by exposure to mild hyperbaric oxygen. Mild hyperbaric oxygen is effective in preventing the progression of Parkinson's disease. Abstract: We examined whether exposure to mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of a neurotoxic animal model with Parkinson's disease. Mice injected with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride and probenecid twice a week were divided into two groups: mice with mild hyperbaric oxygen and those without. The mice with mild hyperbaric oxygen were exposed to 1317 hPa with 45% oxygen for 3 h, three times a week. The decrease in dopaminergic neurons of mice with Parkinson's disease was inhibited by 11 weeks of exposure to mild hyperbaric oxygen. We conclude that exposure to mild hyperbaric oxygen is effective in preventing the progression of Parkinson's disease.