Assessment of the antibiofilm and antiquorum sensing activities of Eucalyptus globulus essential oil and its main component 1, 8-cineole against methicillin-resistant Staphylococcus aureus strains. (May 2018)

• Record Type: Journal Article
• Authors: Merghni, Abderrahmen; Noumi, Emira; Hadded, Ons; Dridi, Neyla; Panwar, Harsh; Ceylan, Ozgur; Mastouri, Maha; Snoussi, Mejdi
• Is Part Of: Microbial pathogenesis. Volume 118(2018)
• Page Start: 74
• Page End: 80
• Publication Date: 2018-05
• Subjects: MRSA -- Biofilm -- Eucalyptus globulus -- 1, 8-Cineole -- Antibacterial -- Antiquorum sensing; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2018.03.006
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Antibacterial resistance is an increasingly serious threat to global public health. The search for new anti-infection agents from natural resources, with different mode of actions and competitive effects became a necessity. In this study, twenty height methicillin-resistant Staphylococcus aureus (MRSA) strains were investigated for their biofilm formation ability. Subsequently, the antibiofilm effects of Eucalyptus globulus essential oil and its main component 1, 8-cineole, against MRSA, as well as their antiquorum sensing potential, were evaluated. Our results displayed the potent efficacy of both E . globulus essential oil and 1, 8-cineole against the development of biofilms formed by the methicillin-resistant strains. Additionally, E . globulus essential oil showed more potent of anti -QS activity, even at a low concentration, when compared to 1, 8-cineole. All these property of tested agents may pave the way to prevent the development of biofilm formation by MRSA and subsequently the spreading of nosocomial infection. Highlights: Methicillin-resistant Staphylococcus aureus (MRSA) strains were investigated for their biofilm formation ability. Antibacterial properties of the E. globulus EO and the 1, 8-cineole, were investigated against characterized MRSA strains. Tested agents showed an interesting antibacterial, antibiofilm, anti-swarming and anti-quorum sensing activities.