Attenuation of Pulse Disturbances in Biomolecular Oscillators. Issue 1 (2018)

• Record Type: Journal Article
• Authors: Banerjee, Soumyadip; Bokka, Venkat; Sen, Shaunak
• Is Part Of: IFAC-PapersOnLine. Volume 51:Issue 1(2018)
• Page Start: 301
• Page End: 306
• Publication Date: 2018
• Subjects: biomolecular oscillator -- limit cycle -- positive feedback control -- settling-time -- time-constant; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2018.05.031
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: Disturbance rejection is an important control objective. While this has been widely investigated when the attractor is a fixed point, the case when the attractor is a limit cycle is generally unclear. Here we address this issue using computational model of a benchmark three-node biomolecular oscillator. We estimate the attenuation of pulsed disturbances in this oscillator using two metrics. We add additional positive/ negative feedback to this and find that the positive feedback can improve the attenuation properties. These results should help in designing controllers for limit cycles.