Neutropenia and Thrombocytopenia Induced By Quetiapine Monotherapy: A Case Report and Review of Literature. Issue 3 (1st September 2016)

• Record Type: Journal Article
• Authors: Arslan, Filiz Civil; Aykut, Demet Saglam; Ince, Canan; Tiryaki, Ahmet
• Is Part Of: Klinik psikofarmakoloji bülteni =. Volume 26:Issue 3(2016)
• Page Start: 319
• Page End: 323
• Publication Date: 2016-09-01
• Subjects: Quetiapine -- neutropenia -- thrombocytopenia; Psychopharmacology -- Periodicals; Psychotropic drugs -- Therapeutic use -- Periodicals; Mental illness -- Treatment -- Periodicals; Psychotropic Drugs -- therapeutic use; Mental Disorders -- drug therapy; Psychopharmacology; Mental illness -- Treatment; Psychopharmacology; Psychotropic drugs -- Therapeutic use; Periodicals; Electronic journals; Periodicals; 615.78
• DOI: 10.5455/bcp.20151219072235
• Languages: English
• ISSNs: 1017-7833

Abstract

ABSTRACT: Antipsychotic drugs can cause neutropenia which can progress to life-threatening agranulocytosis. Clozapine is well-known for this side effect which is rare for other antipsychotics. Quetiapine is a newer atypical antipsychotic which shows similarities with clozapine in chemical structure. We present a rare case of neutropenia and thrombocytopenia induced by quetiapine monotherapy of 600 mg/day in a 69-year-old patient with the diagnosis of bipolar I disorder. Hematological adverse effects were resolved by the discontinuation of quetiapine treatment. Although monitoring blood counts during quetiapine use is not recommended, clinicians should be aware of this rare but hazardous side effect.