Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 Polymorphisms with Alcohol Dependence. Issue 1 (1st March 2016)

• Record Type: Journal Article
• Authors: Sengul, Cem; Erdal, Mehmet Emin; Sengul, Ceyhan Balci; Ay, Ozlem Izci; Buber, Ahmet; Alacam, Huseyin; Ay, Mustafa Ertan; Herken, Hasan
• Is Part Of: Klinik psikofarmakoloji bülteni =. Volume 26:Issue 1(2016)
• Page Start: 15
• Page End: 20
• Publication Date: 2016-03-01
• Subjects: alcohol dependence -- neuropeptide Y -- neurexin -- polymorphism; Psychopharmacology -- Periodicals; Psychotropic drugs -- Therapeutic use -- Periodicals; Mental illness -- Treatment -- Periodicals; Psychotropic Drugs -- therapeutic use; Mental Disorders -- drug therapy; Psychopharmacology; Mental illness -- Treatment; Psychopharmacology; Psychotropic drugs -- Therapeutic use; Periodicals; Electronic journals; Periodicals; 615.78
• DOI: 10.5455/bcp.20151016123639
• Languages: English
• ISSNs: 1017-7833

Abstract

ABSTRACT: Objective : Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods : 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results : Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions : Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.