WebPropagate: A Web Server for Network Propagation. Issue 15 (20th July 2018)

• Record Type: Journal Article
• Authors: Biran, Hadas; Almozlino, Tovi; Kupiec, Martin; Sharan, Roded
• Is Part Of: Journal of molecular biology. Volume 430:Issue 15(2018)
• Page Start: 2231
• Page End: 2236
• Publication Date: 2018-07-20
• Subjects: network diffusion -- protein–protein interaction network -- gene prioritization -- p-value computation -- subnetwork inference; FDR false discovery rate -- PPI protein–protein interaction -- TLM telomere length maintenance; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2018.02.025
• Languages: English
• ISSNs: 0022-2836

Abstract

Abstract: Network propagation is a powerful tool for genetic analysis which is widely used to identify genes and genetic modules that underlie a process of interest. Here we provide a graphical, web-based platform (http://anat.cs.tau.ac.il/WebPropagate/ ) in which researchers can easily apply variants of this method to data sets of interest using up-to-date networks of protein–protein interactions in several organisms. Graphical abstract: Highlights: We propose WebPropagate: a web server that implements network propagation on up-to-date protein–protein interaction networks of four species. WebPropagate produces p -values for the propagation results and corrects them for multiple testing, allowing the identification of significant proteins. WebPropagate produces a graphical display of the subnetwork connecting the significant proteins, facilitating the interpretation of the results.