Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials. (July 2018)

• Record Type: Journal Article
• Authors: Adenis, A.; Alessio, A.; Aouakli, A.; Azzedine, A.; Bedjaoui, A.; Bidault, A.; Blanchi, A.; Botton, A.; Cadier-Lagnes, A.; Fatisse, A.; Gagnaire, A.; Gilbert, A.; Gueye, A.; Hollebecque, A.; Lemaire, A.; Mahamat, A.; Marre, A.; Patenotte, A.; Rotenberg, A.; Roussel, A.; Thirot-Bidault, A.; Votte, A.; Weber, A.; Zaanan, A.; Dupont-Gossart, A.C.; Villing, A.L.; Queuniet, A.M.; Coudert, B.; Denis, B.; Garcia, B.; Lafforgue, B.; Landi, B.; Leduc, B.; Linot, B.; Paillot, B.; Rhein, B.; Winkfield, B.; Barberis, C.; Becht, C.; Belletier, C.; Berger, C.; Bineau, C.; Borel, C.; Brezault, C.; Buffet, C.; Cornila, C.; Couffon, C.; De La Fouchardière, C.; Giraud, C.; Lecaille, C.; Lepere, C.; Lobry, C.; Locher, C.; Lombard-Bohas, C.; Paoletti, C.; Platini, C.; Rebischung, C.; Sarda, C.; Vilain, C.; Briac-Levaché, C.; Auby, D.; Baudet-Klepping, D.; Bechade, D.; Besson, D.; Cleau, D.; Festin, D.; Gargot, D.; Genet, D.; Goldfain, D.; Luet, D.; Malka, D.; Peré-Vergé, D.; Pillon, D.; Sevin-Robiche, D.; Smith, D.; Soubrane, D.; Tougeron, D.; Zylberait, D.; Carola, E.; Cuillerier, E.; Dorval Danquechin, E.; Echinard, E.; Janssen, E.; Maillard, E.; Mitry, E.; Norguet-Monnereau, E.; Suc, E.; Terrebonne, E.; Zrihen, E.; Pariente, E.A.; Almaric, F.; Audemar, F.; Bonnetain, F.; Desseigne, F.; Dewaele, F.; Di Fiore, F.; Ghiringhelli, F.; Husseini, F.; Khemissa, F.; Kikolski, F.; Morvan, F.; Petit-Laurent, F.; Riot, F.; Subtil, F.; Zerouala-Boussaha, F.; Caroli-Bosc, F.X.; Boilleau-Jolimoy, G.; Bordes, G.; Cavaglione, G.; Coulanjon, G.; Deplanque, G.; Gatineau-Saillant, G.; Goujon, G.; Medinger, G.; Roquin, G.; Brixi-Benmansour, H.; Castanie, H.; Lacroix, H.; Maechel, H.; Perrier, H.; Salloum, H.; Senellart, H.; Baumgaertner, I.; Cumin, I.; Graber, I.; Trouilloud, I.; Boutin, J.; Butel, J.; Charneau, J.; Cretin, J.; Dauba, J.; Deguiral, J.; Egreteau, J.; Ezenfis, J.; Forestier, J.; Goineau, J.; Lacourt, J.; Lafon, J.; Martin, J.; Meunier, J.; Moreau, J.; Provencal, J.; Taieb, J.; Thaury, J.; Tuaillon, J.; Vergniol, J.; Villand, J.; Vincent, J.; Volet, J.; Bachet, J.B.; Barbare, J.C.; Souquet, J.C.; Grangé, J.D.; Dor, J.F.; Paitel, J.F.; Jouve, J.L.; Raoul, J.L.; Cheula, J.M.; Gornet, J.M.; Sabate, J.M.; Vantelon, J.M.; Vaillant, J.N.; Aucouturier, J.P.; Barbieux, J.P.; Herr, J.P.; Lafargue, J.P.; Lagasse, J.P.; Latrive, J.P.; Plachot, J.P.; Ramain, J.P.; Robin, J.P.; Spano, J.P.; Douillard, J.Y.; Beerblock, K.; Bouhier-Leporrier, K.; Slimane Fawzi, K.; Cany, L.; Chone, L.; Dahan, L.; Gasnault, L.; Rob, L.; Stefani, L.; Wander, L.; Baconnier, M.; Ben Abdelghani, M.; Benchalal, M.; Blasquez, M.; Carreiro, M.; Charbit, M.; Combe, M.; Duluc, M.; Fayolle, M.; Gignoux, M.; Giovannini, M.; Glikmanas, M.; Mabro, M.; Mignot, M.; Mornet, M.; Mousseau, M.; Mozer, M.; Pauwels, M.; Pelletier, M.; Porneuf, M.; Ramdani, M.; Schnee, M.; Tissot, M.; Zawadi, M.; Clavero-Fabri, M.C.; Gouttebel, M.C.; Kaminsky, M.C.; Galais, M.P.; Abdelli, N.; Barrière, N.; Bouaria, N.; Bouarioua, N.; Delas, N.; Gérardin, N.; Hess-Laurens, N.; Stremsdoerfer, N.; Berthelet, O.; Boulat, O.; Capitain, O.; Favre, O.; Amoyal, P.; Bergerault, P.; Burtin, P.; Cassan, P.; Chatrenet, P.; Chiappa, P.; Claudé, P.; Couzigou, P.; Feydy, P.; Follana, P.; Geoffroy, P.; Godeau, P.; Hammel, P.; Laplaige, P.; Lehair, P.; Martin, P.; Novello, P.; Pantioni, P.; Pienkowski, P.; Pouderoux, P.; Prost, P.; Ruszniewski, P.; Souillac, P.; Texereau, P.; Thévenet, P.; Haineaux, P.A.; Benoit, R.; Coriat, R.; Lamy, R.; Mackiewicz, R.; Beorchia, S.; Chaussade, S.; Hiret, S.; Jacquot, S.; Lavau Denes, S.; Montembault, S.; Nahon, S.; Nasca, S.; Nguyen, S.; Oddou-Lagraniere, S.; Pesque-Penaud, S.; Fratte, S.P.; Chatellier, T.; Mansourbakht, T.; Morin, T.; Walter, T.; Boige, V.; Bourgeois, V.; Derias, V.; Guérin-Meyer, V.; Hautefeuille, V.; Jestin Le Tallec, V.; Lorgis, V.; Quentin, V.; Sebbagh, V.; Veuillez, V.; Adhoute, X.; Coulaud, X.; Becouarn, Y.; Coscas, Y.; Courouble, Y.; Le Bricquir, Y.; Molin, Y.; Rinaldi, Y.; Lam, Y.H.; Ladhib, Z.; Aparicio, Thomas; Ducreux, Michel; Faroux, Roger; Barbier, Emilie; Manfredi, Sylvain; Lecomte, Thierry; Etienne, Pierre-Luc; Bedenne, Laurent; Bennouna, Jaafar; Phelip, Jean-Marc; François, Eric; Michel, Pierre; Legoux, Jean-Louis; Gasmi, Mohamed; Breysacher, Gilles; Rougier, Philippe; De Gramont, Aimery; Lepage, Come; Bouché, Olivier; Seitz, Jean-François;
• Is Part Of: European journal of cancer. Volume 98(2018)
• Page Start: 1
• Page End: 9
• Publication Date: 2018-07
• Subjects: Overweight -- Prognostic factor -- Pooled analysis -- Colorectal cancer -- Bevacizumab; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2018.03.031
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Background: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI. Patients and methods: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5–24) and thin patients (BMI <18.5). Interaction tests were performed between BMI effect and sex, age and the addition of antiangiogenics to chemotherapy. Results: The rate of BMI ≥25 patients was 41.5%, ranging from 37.6% (1991–1999 period) to 41.5% (2000–2006 period) and 44.8% (2007–2013 period). Comparison of overweight patients versus normal BMI range patients revealed a significant improvement of median overall survival (OS) (18.5 versus 16.3 months, HR = 0.88 [0.80–0.98] p = 0.02) and objective response rate (ORR) (42% versus 36% OR = 1.23 [1.01–1.50] p = 0.04) but a comparable median progression-free survival (PFS) (7.8 versus 7.2 months, HR = 0.96 [0.87–1.05] p = 0.35). Subgroup analyses revealed that overweight was significantly associated with better OS in men. OS and PFS were significantly shorter in thin patients. Conclusion: Overweight patients had a prolonged OS compared with normal weight patients with mCRC. The association of overweight with better OS was only observed in men. The pejorative prognosis of BMI <18.5 was confirmed. Highlights: Body mass index of patient enrolled in clinical trial increases across the time period. Overweight patients had a prolonged overall survival compared with normal weight patients. The association of overweight with better OS was only observed in men. Thin patients had a worst overall survival compare to normal weight patients.