Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta. (June 2018)

• Record Type: Journal Article
• Authors: Neradugomma, Naveen K.; Drafton, Kaitlyn; O'Day, Diana R.; Liao, Michael Z.; Han, Lyrialle W.; Glass, Ian A.; Mao, Qingcheng
• Is Part Of: Placenta. Volume 66(2018)
• Page Start: 36
• Page End: 39
• Publication Date: 2018-06
• Subjects: Marijuana -- Cannabinoid -- Cannabinoid receptor -- Placenta -- Uterine endometrium; CNR1 cannabinoid receptor 1 -- CNR2 cannabinoid receptor 2 -- CBs cannabinoids -- eCBs endocannabinoids -- ACTB β-actin; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2018.05.002
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express CNR1 and CNR2 and can respond to cannabinoid signaling. In this study, we show that marijuana use significantly increases mRNA or protein expression of CNR1 and CNR2 in human endometrium from the first and early second trimester pregnancies, with minor effects on placental expression of CNRs. Highlights: Expression of cannabinoid receptors in early pregnancy endometrium. Expression of cannabinoid receptors in early pregnancy placenta. Effects of marijuana use in early pregnancy on cannabinoid receptor expression.