Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up. (August 2015)

• Record Type: Journal Article
• Authors: Hirachi, T; Ishii, H; Tada, Y; Noguchi, T; Haraguchi, Y; Tateishi, H; Mizoguchi, Y; Kato, T A; Kawashima, T; Monji, A
• Is Part Of: Lupus. Volume 24:Number 9(2015)
• Page Start: 990
• Page End: 993
• Publication Date: 2015-08
• Subjects: Systemic lupus erythematosus (SLE) -- relapse -- mania -- single-photon emission computed tomography (SPECT) -- magnetic resonance imaging (MRI); Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203315570161
• Languages: English
• ISSNs: 0961-2033

Abstract

Psychiatric manifestations of systemic lupus erythematosus (SLE) that are commonly preceded by organic syndromes include confusional states, anxiety disorder, cognitive dysfunction, mood disorder and psychosis. A 35-year-old woman was admitted to hospital with a relapse of SLE. Laboratory data were exacerbated, with some physical symptoms, and her primary psychiatric symptom was mania. The symptoms were reduced by treatment with prednisolone, methylprednisolone and aripiprazole. Magnetic resonance imaging and single-photon emission computed tomography (SPECT) using 123 I-IMP was then performed and analyzed with three-dimensional stereotactic surface projection. This case emphasizes that SLE can commence with organic syndromes and relapse with predominantly psychiatric symptoms, and that the treatment efficacy may be confirmed using a follow-up of SPECT.