Thermal hazard investigation of a pharmaceutical intermediate. Issue 2 (11th August 2017)

• Record Type: Journal Article
• Authors: Zhao, Ralph; Muzzio, Dan; Vickery, Tom; Fisher, Elizabeth; Artino, Laura; Yin, Jay; Hinksmon, Joe; Fine, Adam
• Is Part Of: Process safety progress. Volume 37:Issue 2(2018)
• Page Start: 263
• Page End: 267
• Publication Date: 2017-08-11
• Subjects: hazards evaluation -- case history -- thermal hazards -- accelerated reaction calorimetry -- hydrate; Chemical plants -- Management -- Periodicals; 660
• DOI: 10.1002/prs.11917
• Languages: English
• ISSNs: 1066-8527

Abstract

Abstract : During the process development of a pharmaceutical advanced intermediate, new chemistry using an aqueous workup resulted in the discovery of a new hydrated crystal form of this intermediate. This hydrated crystal form showed thermal instability at a relatively low temperature compared to the original anhydrous form. Thermal stability and associated process safety hazards were investigated in order to ensure process safety and transportation safety of this intermediate. © 2017 American Institute of Chemical Engineers Process Saf Prog 37: 263–267, 2018