Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement. Issue 3 (25th March 2018)

• Record Type: Journal Article
• Authors: Yamazaki, Rie; Kikuchi, Taku; Kato, Jun; Sakurai, Masatoshi; Koda, Yuya; Hashida, Risa; Yamane, Yusuke; Abe, Ryohei; Hasegawa, Naoki; Okamoto, Shinichiro; Mori, Takehiko
• Is Part Of: Transplant infectious disease. Volume 20:Issue 3(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-25
• Subjects: allogeneic hematopoietic stem cell transplantation -- immunoglobulin G2 deficiency -- Pneumonia -- Streptococcus pneumoniae; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12863
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.