Hematite‐Based Photoelectrode Materials for Photoelectrocatalytic Inhibition of Alzheimer's β‐Amyloid Self‐Assembly. Issue 8 (14th February 2017)

• Record Type: Journal Article
• Authors: Kim, Kayoung; Lee, Byung Il; Chung, You Jung; Choi, Woo Seok; Park, Chan Beum
• Is Part Of: Advanced healthcare materials. Volume 6:Issue 8(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-14
• Subjects: Alzheimer's disease -- β‐amyloid peptides -- hematite -- photoanode materials -- self‐assembly; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201601133
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : A visible light‐active, hematite‐based photoelectrode platform for suppressing β‐amyloid (Aβ) self‐assembly in vitro is reported. Upon illumination of a light‐emitting diode with an anodic bias, the hematite photoanode generates reactive radical species, such as superoxide ions and hydroxyl radicals, via photoelectrocatalytic process. According to our analyses, the hematite photoanode exhibited a strong inhibitory effect on Aβ aggregation under visible light illumination and anodic bias. We found that hole‐derived radicals played a significant role of oxidizing Aβ peptides, which effectively blocked further aggregation. The efficacy of photoelectrocatalytic inhibition on Aβ aggregation was enhanced by introducing cobalt phosphate (Co‐Pi) as a co‐catalyst on the hematite photoanode, which facilitated the separation of electron‐hole pairs. We verified that both bare and Co‐Pi@hematite photoanodes are biocompatible and effective in reducing Aβ aggregation‐induced cytotoxicity. Abstract : Hematite‐based photoelectrode platforms effectively inhibit β‐amyloid (Aβ) aggregation through photoelectrocatalytic process. Upon illumination under anodic bias, the hematite photoanode generates hole‐derived radicals (e.g., hydroxyl radicals, OH·) that trigger the oxidation of Aβ residues, blocking further aggregation. The cobalt phosphate co‐catalyst deposited on the hematite photoanode enhances the inhibitory effect of the photoanode on Aβ aggregation.