Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura. (August 2015)

• Record Type: Journal Article
• Authors: Sintas, Cèlia; Fernández-Morales, Jèssica; Vila-Pueyo, Marta; Narberhaus, Bernat; Arenas, Concepció; Pozo-Rosich, Patricia; Macaya, Alfons; Cormand, Bru
• Is Part Of: Cephalalgia. Volume 35:Number 9(2015)
• Page Start: 776
• Page End: 782
• Publication Date: 2015-08
• Subjects: Migraine with aura -- association study -- PRDM16 -- TRPM8 -- TSPAN2 -- MMP16; Headache -- Periodicals; 616.8491
• DOI: 10.1177/0333102414557841
• Languages: English
• ISSNs: 0333-1024

Abstract

Background: Migraine is a common disabling condition that affects approximately 15% of the population. Several genome-wide association studies have attempted to identify susceptibility variants involved in migraine, reporting several candidate loci for the disorder. Methods: In order to replicate findings from previous genome-wide association studies, a case–control association study was performed. Twelve single nucleotide polymorphisms were genotyped in a Spanish sample of 512 migraine with aura patients and 535 migraine-free controls. Results: Nominal associations were found for single nucleotide polymorphisms rs2651899 (within the PRDM16 gene), rs10166942 (near TRPM8 ), rs12134493 (close to TSPAN2 ) and rs10504861 (near MMP16 ) in our migraine with aura sample. Conclusions: Our study provides suggestive replication, in a Spanish migraine with aura sample, of four genome-wide association study findings previously reported in common migraine. However, larger sample sets should be explored to confirm our results.