A course‐based undergraduate research experience investigating the consequences of nonconserved mutations in lactate dehydrogenase. Issue 3 (7th March 2018)

• Record Type: Journal Article
• Authors: Ayella, Allan; Beck, Moriah R.
• Is Part Of: Biochemistry and molecular biology education. Volume 46:Issue 3(2018)
• Page Start: 285
• Page End: 296
• Publication Date: 2018-03-07
• Subjects: Course‐based undergraduate research experience -- enzymes and catalysis -- protein structure and function -- biochemistry laboratory; Biochemistry -- Study and teaching -- Periodicals; Molecular biology -- Study and teaching -- Periodicals; 572.071
• DOI: 10.1002/bmb.21115
• Languages: English
• ISSNs: 1470-8175

Abstract

Abstract: There is a growing movement to involve undergraduate students in authentic research experiences. A variety of studies have indicated the strength of this approach in developing scientific aptitude, confidence, critical thinking skills, and increasing the likelihood to become career scientists. Course‐based undergraduate research experiences (CUREs) foster opportunities for students to carry out authentic research at both primarily undergraduate and large research institutions. Here, we describe a novel CURE‐based biochemistry laboratory course to explore the consequences of mutagenesis of non‐conserved amino acid sites in the structure and function of the lactate dehydrogenase enzyme and demonstrate how collaborations between institutions can facilitate real research experiences at any type of institution. © 2018 by The International Union of Biochemistry and Molecular Biology, 46(3):285–296, 2018.