Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells. Issue 5 (26th February 2018)

• Record Type: Journal Article
• Authors: Kim, Sang‐Woo; Lee, Yeon Kyung; Hong, Jeong Hee; Park, Jun‐Young; Choi, Young‐Ae; Lee, Dong Un; Choi, Jungil; Sym, Sun Jin; Kim, Sang‐Hyun; Khang, Dongwoo
• Is Part Of: Advanced science. Volume 5:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-02-26
• Subjects: homing abilities -- in vivo safety -- lung tumors -- mesenchymal stem cells -- mutual destruction -- nanodrug membrane conjugation; Science -- Periodicals; 505
• DOI: 10.1002/advs.201700860
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity. Abstract : Lung cancer targetable fluorescent mesenchymal stem cells are armed with anti‐cancer nanodrugs in blood vessels and are shown to be selectively homing to lung tumor sites and mutually destructive with lung cancer cells. Using this method, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity.