Passive Smoking and Risk of Colorectal Cancer: A Meta-analysis of Observational Studies. (July 2016)

• Record Type: Journal Article
• Authors: Yang, Chen; Wang, Xin; Huang, Chang-hao; Yuan, Wei-jie; Chen, Zi-hua
• Is Part Of: Asia-Pacific journal of public health. Volume 28:Number 5(2016:Sep.)
• Page Start: 394
• Page End: 403
• Publication Date: 2016-07
• Subjects: cancer prevention -- colorectal cancer -- environmental tobacco smoke -- meta-analysis -- passive smoking; Public health -- Pacific Area -- Periodicals; Public health -- Asia -- Periodicals; 362.1095
• DOI: 10.1177/1010539516650724
• Languages: English
• ISSNs: 1010-5395

Abstract

We conducted this meta-analysis to explore the association between passive smoking and the risk of colorectal cancer. A literature search of online databases, including MEDLINE, EMBASE, the Cochrane Library, and Web of Science was performed up to June 30, 2015. A fixed-effects meta-analysis using Stata 12.0 was carried out to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for the associations. Eleven articles, including 6 case-control studies and 6 cohort studies, were included in our analysis according to inclusion and exclusion criteria. The pooled RR of all studies showed a statistically significant association between passive smoking and colorectal cancer (RR = 1.14; 95% CI = 1.05-1.24). Results of subgroup analysis showed a positive association between passive smoking and rectal cancer ((RR = 1.33; 95% CI = 1.15-1.53) and that male passive smokers were at greater risks of colorectal cancer (RR = 1.73; 95% CI = 1.37-2.19) than females. Results suggested that passive smoking is associated with an increased risk of colorectal cancer.