Tissue Engineering: A Modular Strategy to Engineer Complex Tissues and Organs (Adv. Sci. 5/2018). Issue 5 (May 2018)

• Record Type: Journal Article
• Authors: Dikina, Anna D.; Alt, Daniel S.; Herberg, Samuel; McMillan, Alexandra; Strobel, Hannah A.; Zheng, Zijie; Cao, Meng; Lai, Bradley P.; Jeon, Oju; Petsinger, Victoria Ivy; Cotton, Calvin U.; Rolle, Marsha W.; Alsberg, Eben
• Is Part Of: Advanced science. Volume 5:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-05
• Subjects: composite tissue -- microparticle -- regenerative medicine -- tissue engineering -- trachea; Science -- Periodicals; 505
• DOI: 10.1002/advs.201870028
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In article number1700402, Eben Alsberg and co‐workers report the engineering of tri‐tissue tracheas using a scaffold‐free approach that allows for the integration of structural cartilage rings, prevascular blood vessel networks, and epithelial cells into a single construct. Neotracheas of various dimensions, including human size, are formed via cellular self‐assembly. Prevascular tracheas are subcutaneously implanted into mice and demonstrate anastamosis with and perfusion by host vasculature.