Genomic sequences of HLA‐A*68:169, HLA‐B*07:298 and HLA‐B*39:129. (8th March 2018)

• Record Type: Journal Article
• Authors: Balas, A.; Planelles, D.; Rodríguez‐Cebriá, M.; Puig, N.; Vicario, J. L.
• Is Part Of: International journal of immunogenetics. Volume 45:Number 3(2018:Jun.)
• Page Start: 140
• Page End: 142
• Publication Date: 2018-03-08
• Subjects: HLA class I -- new alleles -- sequencing; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12360
• Languages: English
• ISSNs: 1744-3121

Abstract

Summary: Three new HLA class I alleles were described in the Spanish population. HLA‐A*68:169 and ‐B*39:129 show one amino acid replacement at the α1‐domain, compared to A*68:02 (P47 > L47) and ‐B*39:06 (S11 > A11), respectively. HLA‐B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position −14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA‐B genes.