Maneuverability of Magnetic Nanomotors Inside Living Cells. Issue 22 (10th April 2018)

• Record Type: Journal Article
• Authors: Pal, Malay; Somalwar, Neha; Singh, Anumeha; Bhat, Ramray; Eswarappa, Sandeep M.; Saini, Deepak K.; Ghosh, Ambarish
• Is Part Of: Advanced materials. Volume 30:Issue 22(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-04-10
• Subjects: intracellular environments -- magnetic propulsion -- mechanical mapping -- nanomanipulation -- nanomotors; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201800429
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Spatiotemporally controlled active manipulation of external micro‐/nanoprobes inside living cells can lead to development of innovative biomedical technologies and inspire fundamental studies of various biophysical phenomena. Examples include gene silencing applications, real‐time mechanical mapping of the intracellular environment, studying cellular response to local stress, and many more. Here, for the first time, cellular internalization and subsequent intracellular manipulation of a system of helical nanomotors driven by small rotating magnetic fields with no adverse effect on the cellular viability are demonstrated. This remote method of fuelling and guidance limits the effect of mechanical transduction to cells containing external probes, in contrast to ultrasonically or chemically powered techniques that perturb the entire experimental volume. The investigation comprises three cell types, containing both cancerous and noncancerous types, and is aimed toward analyzing and engineering the motion of helical propellers through the crowded intracellular space. The studies provide evidence for the strong anisotropy, heterogeneity, and spatiotemporal variability of the cellular interior, and confirm the suitability of helical magnetic nanoprobes as a promising tool for future cellular investigations and applications. Abstract : Helical nanomotors driven by small magnetic fields are internalized and subsequently maneuvered within living cells (both cancerous and noncancerous). Their maneuverability is sensitive to the tremendous complexity and heterogeneity of the intracellular space, and yet it is possible to engineer their motion with exquisite control, with no adverse effect on the cellular viability.