Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo. Issue 23 (30th April 2018)

• Record Type: Journal Article
• Authors: Yang, Zhen; Dai, Yunlu; Yin, Chao; Fan, Quli; Zhang, Wansu; Song, Justin; Yu, Guocan; Tang, Wei; Fan, Wenpei; Yung, Bryant C.; Li, Jie; Li, Xiang; Li, Xiangchun; Tang, Yufu; Huang, Wei; Song, Jibin; Chen, Xiaoyuan
• Is Part Of: Advanced materials. Volume 30:Issue 23(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-04-30
• Subjects: cisplatin -- ratiometric photoacoustic imaging -- ROS generation -- synergistic cancer therapy -- theranostics; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201707509
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Enhancing the generation of reactive oxygen species (ROS) is an effective anticancer strategy. However, it is a great challenge to control the production and to image ROS in vivo, both of which are vital for improving the efficacy and accuracy of cancer therapy. Herein, an activatable semiconducting theranostic nanoparticle (NP) platform is developed that can simultaneously enhance ROS generation while self‐monitoring its levels through ratiometric photoacoustic (PA) imaging. The NP platform can further guide in vivo therapeutic effect in tumors. The theranostic NP platform is composed of: (i) cisplatin prodrug and ferric ion catalyst for ROS generation, a part of combination cancer therapy; and (ii) a ratiometric PA imaging nanoprobe consisting of inert semiconducting perylene‐diimide (PDI) and ROS activatable near‐infrared dye (IR790s), used in ratiometric PA imaging of ROS during cancer treatment. Ratiometric PA signals are measured at two near‐infrared excitation wavelengths: 680 and 790 nm for PDI and IR790s, respectively. The measurements show highly accurate visualization of OH generation in vivo. This novel ROS responsive organic theranostic NP allows not only synergistic cancer chemotherapy but also real‐time monitoring of the therapeutic effect through ratiometric PA imaging. Abstract : An activatable semiconducting perylene diimide (PDI)‐based theranostic nanoplatform is developed that can simultaneously enhance reactive oxygen species generation and self‐monitor its levels by ratiometric photoacoustic imaging in vivo. They can be further used to track the strong anticancer chemotherapy effect in vivo.