Theophylline as an adjunct to control malignant ventricular arrhythmia associated with early repolarization. Issue 5 (7th December 2017)

• Record Type: Journal Article
• Authors: Perrin, Tilman; Guieu, Regis; Koutbi, Linda; Franceschi, Frédéric; Hourdain, Jérôme; Brignole, Michele; Deharo, Jean‐Claude
• Is Part Of: Pacing and clinical electrophysiology. Volume 41:Issue 5(2018)
• Page Start: 444
• Page End: 446
• Publication Date: 2017-12-07
• Subjects: adenosine -- early repolarization -- hydroquinidine -- theophylline -- ventricular arrhythmia; Cardiac pacing -- Periodicals; Electrophysiology -- Periodicals; 617.4120645
• DOI: 10.1111/pace.13240
• Languages: English
• ISSNs: 0147-8389

Abstract

Abstract: Early repolarization (ER) has been associated with an increased risk of sudden cardiac arrest. Interestingly, ventricular arrhythmias seem to be triggered by parasympathetic stimulation. In the present case report, we describe complete control of highly frequent malignant ventricular arrhythmias after adding theophylline to ineffective oral hydroquinidine and high‐rate pacing in a patient suffering from malignant ER. We hypothesize that the theophylline‐mediated enhanced beta‐adrenergic stimulation could reduce the transmural myocardial voltage discrepancy by increasing the inward ICa, L current.