Stem cell mobilization kinetics in elderly patients with multiple myeloma. Issue 2 (April 2018)

• Record Type: Journal Article
• Authors: Dogu, Mehmet Hilmi; Batgi, Hikmetullah; Erkurt, Mehmet Ali; Hacioglu, Sibel; Tekgunduz, Emre; Kaya, Emin; Iskender, Dicle; Eren, Rafet; Kuku, Irfan; Altuntas, Fevzi
• Is Part Of: Transfusion and apheresis science. Volume 57:Issue 2(2018)
• Page Start: 204
• Page End: 207
• Publication Date: 2018-04
• Subjects: Multiple myeloma -- Mobilization -- Apheresis; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2018.01.010
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: In this study, we aimed to investigate whether the procedure and product kinetics differ according to age groups in advanced-age MM patients who underwent autologous HSCT. 59 patients who underwent autologous HSCT were retrospectively analyzed. Then, the patients were divided into two groups as 60–65 years and ≥65 years. It was significantly lower in ≥65 years group (p = 0.008) and proportionally, the procedure duration was also significantly shortened in this group (p = 0.013). Total number of collected CD34 positive stem cells was 6.20 × 106 (±3.83) in 60–65 years group while it was 5.51 × 106 (±2.48) in ≥65 years group with no statistically significant difference (p = 0.825). In conclusion, there was no significant difference in terms of the number of collected CD34-positive stem cells in this study that investigates the mobilization data, procedure and product kinetics, we think that successful stem cell mobilization can be performed in appropriately selected patients regardless of age.