Current Concepts in Meniscus Tissue Engineering and Repair. Issue 11 (15th March 2018)

• Record Type: Journal Article
• Authors: Bilgen, Bahar; Jayasuriya, Chathuraka T.; Owens, Brett D.
• Is Part Of: Advanced healthcare materials. Volume 7:Issue 11(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-15
• Subjects: biomaterials -- meniscus -- progenitors -- regenerative medicine -- tissue engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201701407
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The meniscus is the most commonly injured structure in the human knee. Meniscus deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal mechanical forces, and replacement strategies for this structure have lagged behind other tissue engineering endeavors. The challenges include the complex 3D structure with individualized size parameters, the significant compressive, tensile and shear loads encountered, and the poor blood supply. In this progress report, a review of the current clinical treatments for different types of meniscal injury is provided. The state‐of‐the‐art research in cellular therapies and novel cell sources for these therapies is discussed. The clinically available cell‐free biomaterial implants and the current progress on cell‐free biomaterial implants are reviewed. Cell‐based tissue engineering strategies for the repair and replacement of meniscus are presented, and the current challenges are identified. Tissue‐engineered meniscal biocomposite implants may provide an alternative solution for the treatment of meniscal injury to prevent OA in the long run, because of the limitations of the existing therapies. Abstract : The meniscus is the most commonly injured structure in the human knee. In this progress report, the current clinical treatments and the state‐of‐the‐art research in cellular therapies, biomaterials, and cell‐based tissue engineering strategies for the repair and replacement of meniscus are reviewed, and the current challenges are identified.