Augmentation of the Inotropic Effects of Dopamine Following Linezolid Administration in an Infant. (August 2016)

• Record Type: Journal Article
• Authors: Lovett, Marlina E.; Estrada, Maria; Sargel, Cheryl; Tobias, Joseph D.
• Is Part Of: Journal of intensive care medicine. Volume 31:Number 7(2016)
• Page Start: 490
• Page End: 492
• Publication Date: 2016-08
• Subjects: hypertension -- linezolid -- inotropic agents -- monoamine oxidase -- dopamine; Critical care medicine -- Periodicals; Critical Care -- Periodicals; Soins intensifs -- Périodiques; Soins intensifs; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.02805
• DOI: 10.1177/0885066615627777
• Languages: English
• ISSNs: 0885-0666

Abstract

Although generally safe and effective, one of the unique properties of linezolid is its weak inhibitory effect on monoamine oxidase. As such, it may interact with other medications that act through the adrenergic or serotonergic systems, including selective-serotonin reuptake inhibitors and vasoactive agents. We present a 3-month-old infant who was being treated with dopamine to maintain mean arterial pressure during mechanical ventilation following viral-induced respiratory failure. Hypertension and tachycardia developed during the administration of linezolid on two separate occasions. The physiology of catecholamine metabolism is reviewed including the role of the monoamine oxidase system. The potential interaction between linezolid and vasoactive agents such as dopamine is discussed.