Elimination profile of triamcinolone in urine following oral administration. Issue 5 (11th December 2017)

• Record Type: Journal Article
• Authors: Chen, Ting‐Ting; Tseng, Yi‐Chun; Huang, Tai‐Yuan; Chang‐Chien, Guo‐Ping; Hsu, Mei‐Chich
• Is Part Of: Drug testing and analysis. Volume 10:Issue 5(2018)
• Page Start: 860
• Page End: 864
• Publication Date: 2017-12-11
• Subjects: doping -- glucocorticoid -- oral route -- triamcinolone; Drugs -- Analysis -- Periodicals; Drug testing -- Periodicals; Chemistry, Forensic -- Periodicals; 615.1901
• DOI: 10.1002/dta.2343
• Languages: English
• ISSNs: 1942-7603

Abstract

Abstract: Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti‐Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit (MRPL) for urinary T is 30 ng/mL. However, the data about the urinary excretion of T after oral administration is limited. We investigate the elimination profile and determine whether single‐dose administration of T would cause a positive doping result. Twelve healthy volunteers received a single‐dose of 4‐mg T rally, and urine samples were collected for 24 hours. A validated liquid chromatography–tandem mass spectrometry method was used to determine urinary T levels. Non‐compartmental modeling was used to estimate the pharmacokinetic parameters. All the urinary T concentrations were much higher than the MRPL. The peak urinary T concentration was 3211.4 ± 860.3 ng/mL (mean ± SD), time to peak concentration was 1.7 ± 0.9 hours, and the estimated elimination half‐life was 4.4 ± 2.8 hours. About 27.76% of the consumed dose was eliminated via urine within 24 hours of intake. After a single‐dose oral administration, urinary T concentrations still exceeded the MRPL after 24 hours. This information could be useful for limiting the misuse of T. Athletes should be aware when using T in competition and acquire approval for a therapeutic use exemption prior to use. Moreover, the elimination profile of orally administered T may be crucial information for distinguishing different dosage routes. Abstract : After a single‐dose oral administration of triamcinolone, urinary concentrations of triamcinolone still exceeded the MRPL after 24 h. The urinary triamcinolone level was much higher 24 h after receiving triamcinolone orally than after a local injection. The elimination profile of orally administered triamcinolone may be crucial information for distinguishing different dosage routes.