Comparative Review of Outcomes in Patients With Congenital Heart Disease Requiring Cardiopulmonary Support for Failure to Wean From Cardiopulmonary Bypass or for Refractory Sudden Cardiac Arrest. (July 2015)

• Record Type: Journal Article
• Authors: Pourmoghadam, Kamal K.; Olsen, Monica C.; Nguyen, Moui; O'Brien, Michael C.; DeCampli, William M.
• Is Part Of: World journal for pediatric & congenital heart surgery. Volume 6:Number 3(2015:Jul.)
• Page Start: 387
• Page End: 392
• Publication Date: 2015-07
• Subjects: ECMO (extracorporeal membrane oxygenation) -- congenital heart disease (CHD) -- congenital heart surgery -- heart failure; Pediatric cardiology -- Periodicals; Congenital heart disease in children -- Periodicals; Heart -- Abnormalities -- Surgery -- Periodicals; Heart -- Surgery -- Periodicals; Heart Defects, Congenital -- surgery -- Periodicals; Cardiac Surgical Procedures -- Periodicals; Child -- Periodicals; Adult -- Periodicals; 618.9212
• DOI: 10.1177/2150135115581388
• Languages: English
• ISSNs: 2150-1351

Abstract

Background: We reviewed the outcomes of patients who underwent cardiopulmonary support (CPS) for either refractory sudden cardiac arrest or failure to wean from cardiopulmonary bypass (CPB). Methods: Between January 2005 and July 2013, 37 patients with congenital heart disease (CHD) underwent 39 instances of CPS for sudden cardiac arrest as extracorporeal cardiopulmonary resuscitation (E-CPR; group I, n = 19) or for failure to wean from CPB (group II, n = 20). Univariate analyses determined which variables differed among the groups and which had significant association with hospital survival. Binary logistic regression determined the significant associations in a multivariable model. Results: Overall 30-day and hospital survival were 76.9% (30) and 69.2% (27), respectively. For groups I and II, hospital survival was 68.4% (13) and 70.0% (14), respectively. Variables associated with mortality in the univariate analysis included hours on CPS ( P = .045), initial aspartate aminotransferase (AST) level on CPS ( P = .007), and bicarbonate 24 hours on CPS ( P = .004). Logistic regression showed single-ventricle physiology ( P = .05), initial AST level on CPS ( P = .03), and lower bicarbonate 24 hours on CPS ( P = .026) to be significantly associated with mortality. Conclusions: Comparable rates of survival to discharge can be obtained when CPS is initiated for E-CPR or for failure to wean from CPB in resuscitating patients with CHD. Hepatic and renal factors indicative of inadequate early tissue perfusion, single-ventricle physiology, and lower bicarbonate level are factors associated with poor outcome.