Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system. Issue 11 (12th June 2018)

• Record Type: Journal Article
• Authors: Nosrati, Hamed; Javani, Elham; Salehiabar, Marziyeh; Kheiri Manjili, Hamidreza; Davaran, Soodabeh; Danafar, Hossein
• Is Part Of: Journal of materials research. Volume 33:Issue 11(2018)
• Page Start: 1602
• Page End: 1611
• Publication Date: 2018-06-12
• Subjects: magnetic nanoparticles, -- biomaterial, -- ferromagnetic, -- hemolysis, -- drug delivery, -- chrysin, -- nanostructure; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1557/jmr.2018.148
• Languages: English
• ISSNs: 0884-2914

Abstract

Abstract: Abstract : In this project, we described the production of chrysin-loaded L-phenyl alanine (Phe)-coated iron oxide magnetic nanoparticles (chrysin@Phe@IOMNs). chrysin@Phe@IOMNs were characterized by X-ray diffraction, thermogravimetric analysis, fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. Next, hemocompatibility and biocompatibility of Phe-coated IOMNs were determined by hemolysis and MTT assays on HFF-2 and HEK-293 cell lines, respectively. Finally, the anticancer activity of chrysin@Phe@IOMNs was examined on MCF-7 cell line. The outcomes direct that as-prepared nanocarriers are nontoxic and biocompatible and also chrysin@Phe@IOMNs are appropriate for chrysin delivery and other hydrophobic therapeutic agents.