Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design. (3rd April 2018)

• Record Type: Journal Article
• Authors: Kazi, Ada; Chuah, Candy; Majeed, Abu Bakar Abdul; Leow, Chiuan Herng; Lim, Boon Huat; Leow, Chiuan Yee
• Is Part Of: Pathogens and global health. Volume 112:Number 3(2018)
• Page Start: 123
• Page End: 131
• Publication Date: 2018-04-03
• Subjects: Antigen -- bioinformatics -- epitope prediction -- human leukocyte antigen (HLA) -- major histocompability (MHC) -- immunoinformatics -- in silico tools -- reverse vaccinology -- vaccine design; Communicable diseases -- Periodicals; Public health -- International cooperation -- Periodicals; World health -- Periodicals; 362.1969
• DOI: 10.1080/20477724.2018.1446773
• Languages: English
• ISSNs: 2047-7724

Abstract

Abstract: Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tools which can be used to lessen the time and cost required for vaccine and antibody development. This approach allows the selection of immunogenic regions from the pathogen genomes. The ideal regions could be developed as potential vaccine candidates to trigger protective immune responses in the hosts. At present, epitope-based vaccines are attractive concepts which have been successfully trailed to develop vaccines which target rapidly mutating pathogens. In this article, we provide an overview of the current progress of immunoinformatics and their applications in the vaccine design, immune system modeling and therapeutics.