Analysis of Solanum Americanum Mill. by Ultrafast Liquid Chromatography with Diode Array and Time-Of-flight Mass Spectrometry Detection with Evaluation of Anti-Inflammatory Properties in Rodent Models. (2nd September 2018)

• Record Type: Journal Article
• Authors: Vagula, Julianna M.; Rocha, Bruno A.; Silva, Alexandre R.; Narain, Narendra; Bersani-Amado, Ciomar A.; Junior, Oscar O. S.; Visentainer, Jesuí V.
• Is Part Of: Analytical letters. Volume 51:Number 13(2018)
• Page Start: 1973
• Page End: 1985
• Publication Date: 2018-09-02
• Subjects: Acute inflammation -- native plants -- phenolic compounds -- solanaceae -- ultrafast liquid chromatography with diode array and time-of-flight mass spectrometry (UFLC-DAD/TOF-MS); Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Abstracts; 543
• DOI: 10.1080/00032719.2017.1399413
• Languages: English
• ISSNs: 0003-2719

Abstract

ABSTRACT: Solanum americanum Mill. has been traditionally used for the treatment of fever, stomachache, skin diseases, gynecological disorders, and different kinds of inflammation. This study evaluated the anti-inflammatory response of different extracts obtained from ripe fruits of S. americanum Mill., in experimental models and evaluated them qualitatively using ultrafast liquid chromatography with diode array and time-of-flight mass spectrometry (UFLC-DAD/TOF-MS). The inflammatory response of four extracts of ripe fruits was evaluated for the systemic and topical anti-inflammatory activities. The compounds in each extract were identified using UFLC-DAD-TOF/MS. A total of 34 compounds was identified in the four extracts. The best results were obtained in compounds from the aqueous and chloroform extracts. This study demonstrated a significant anti-inflammatory activity for the compounds present in fruit of S. americanum Mill.